Mouse IL-1RL2, recombinant (C-Fc)

Recombinant Mouse Interleukin-1 Receptor-like 2 is produced by our Mammalian expression system and the target gene encoding Asp22-Arg338(Ala158Val) is expressed with a human IgG1 Fc tag at the C-terminus. Protein function: Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36- dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response, it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway. [The UniProt Consortium]