Mouse EPHB2 Protein

Recombinant Mouse EPHB2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val19-Leu543. EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated pathologic characteristics of glioblastoma multiforme (GBM) such as invasion and migration. EPHB2 is epigenetically overexpressed in hypoxia, a condition highly prevalent in malignancy. Furthermore, HIF-2alpha is required for EPHB2 stabilization by hypoxia.