LRP-6 Protein, Human, Recombinant (mFc)

Description: Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/beta-catenin signaling, effectively inhibits pericyte activation, detachment, and transition to myofibroblasts in vivo in response to kidney injury, resulting in attenuated fibrogenesis, capillary rarefaction, and inflammation.LRP-6 interacts closely with PDGF receptor beta and TGF-beta receptor 1 at the cell membrane, suggesting that it may have roles in pathways other than WNT/beta-catenin.