Killer cell immunoglobulin-like receptor 2DS3 (KIR2DS3), partial, human, recombinant

Organism: Homo sapiens (Human). Source: Yeast. Expression Region: 22-245aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: HEGFRRKPSL LAHPGRLVKS EETVILQCWS DVMFEHFLLH REGTFNDTLR LIGEHIDGVS KANFSIGRMR QDLAGTYRCY GSVPHSPYQF SAPSDPLDIV ITGLYEKPSL SAQPGPTVLA GESVTLSCSS WSSYDMYHLS TEGEAHERRF SAGPKVNGTF QADFPLGPAT QGGTYRCFGS FHDSPYEWSK SSDPLLVSVT GNPSNSWPSP TEPSSKTGNP RHLH. Purity: Greater than 90% as determined by SDS-PAGE. Endotoxin: Not test. Biological Activity: n/a. Form: Liquid or Lyophilized powder. Buffer: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 °C/-80 °C. Our default final concentration of glycerol is 50%. Customers could use it as reference. Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 °C/-80 °C. The shelf life of lyophilized form is 12 months at -20 °C/-80 °C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week. Relevance: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Reference: "Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands." Becker S., Tonn T., Fussel T., Uhrberg M., Bogdanow M., Seifried E., Seidl C. Hum. Immunol. 64:183-193(2003). Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.