IL-1R3/IL-1 RAcP, His, Mouse

Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1alpha, IL-1beta, IL-33, IL-36alpha, IL-36beta and IL-36gamma). In many diseases, multiple cytokines contribute to disease pathogenesis. For example, in asthma, both IL-33 and IL-1 are of major importance, as are IL-36 and IL-1 in psoriasis.