Human MERTK/Mer Protein

Recombinant Human MERTK/Mer Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Ala21-Ile505. MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans.