Human MECP2, recombinant (C-6His)

Recombinant Human Methyl-CpG-binding Protein 2 is produced by our Mammalian expression system and the target gene encoding Met1-Ser486 is expressed with a 6His tag at the C-terminus. Protein function: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC). [The UniProt Consortium]