Human LILRB4, recombinant (C-mIgG2a Fc)

Recombinant Human Leukocyte immunoglobulin-like receptor subfamily B member 4 is produced by our Mammalian expression system and the target gene encoding Gln22-Glu259 is expressed with a mouse IgG2a Fc tag at the C-terminus. Protein function: Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. [The UniProt Consortium]