Human JAG1, recombinant (C-Fc)

Recombinant Human Jagged-1 is produced by our Mammalian expression system and the target gene encoding Gln34-Ser1046 is expressed with a human IgG1 Fc tag at the C-terminus. Protein function: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). [The UniProt Consortium]