Human IL-31RA, recombinant (C-6His)

Recombinant Human Interleukin-31 receptor subunit alpha is produced by our Mammalian expression system and the target gene encoding Ala20-Ser516 is expressed with a 6His tag at the C-terminus. Protein function: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700). May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. [The UniProt Consortium]