Human IL-17RE Protein

Recombinant Human IL-17RE Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Thr155-His454. IL-17RE is an orphan receptor of the IL-17 receptor family. It is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection. IL-17RE is also identified as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens. Protein function: Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. [The UniProt Consortium]