Hsp40 (human recombinant)

Heat shock protein 40 (Hsp40) is an Hsp70 co-chaperone protein that regulates the ATP-dependent binding of Hsp70 (Cay-23002, Cay-22739) to target proteins. There are 44 members of the Hsp40 family in humans, and each Hsp40 contains a unique polypeptide-binding domain that binds and delivers specific target proteins to Hsp70. Hsp40 also contains a conserved HPD tripeptide that is critical to its role in driving conversion of Hsp70 from its ATP-bound form to its ADP-bound form to facilitate target loading.Synonyms: Heat Shock Protein 40. Purity: >90% estimated by SDS-PAGE. Source: Recombinant, full-length, N-terminal histidine-tagged Hsp40 protein purified from E. coli. Amino Acids: 2-340 (full length). MW: 40.1 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 8.0, 150 mM sodium chloride, and 10% glycerol. UniProt Accession #: P25685.