Hsc70 (human, recombinant)

Hsc70 is a chaperone from the Hsp70 chaperone family encoded by the HspA8 gene that shares 85% sequence identity to Hsp70 (encoded by HspA1A gene), and is one of the constitutively expressed members from this family. Hsc70 acts as the main housekeeping protein but is also involved in many functions such as ubiquitin-proteasome degradation pathway and transporting cytoplasmic proteins into the nucleus. Hsc70 also garnered interests as a potential therapeutic target since promoting accumulation of unfolded proteins can serve as a potential strategy to cause tumor death.Synonyms: Heat Shock Cognate 70. Purity: >90% estimated by SDS-PAGE. Source: N-terminal Histidine-tagged Hsc70 (human, recombinant) expressed in E. coli. Amino Acids: 2-646 (full length). MW: 72.9 kDa. Formulation: (Request formulation change), 50 mM HEPES, pH 8.0, and 150 mM sodium chloride. UniProt Accession #: P11142.