Histone H2A (Xenopus, recombinant)

Histone H2A is a core histone that forms a dimer with histone H2B. Two histone H2A/H2B dimers form an octameric nucleosome with a histone H3/H4 tetramer, around which DNA wraps, allowing it to be condensed. Histone H2A can be post-translationally modified via methylation of the arginine at position 3 by protein arginine methyltransferase 1 (PRMT1), PRMT5, or PRMT6, which is associated with both transcriptional activation and repression. When methylated by PRMT7, it is associated with DNA damage repair. The arginine residue at position 3 of histone H2A is also subject to citrullination by protein arginine deiminase 4 (PAD4). Histone H2A is ubiquitinated by ubiquitin-specific protease 12 (USP12) during the gastrula stage of Xenopus development. The post-translational modifications on histone H2A vary between each stage of Xenopus development and are enriched on nucleosomes in Xenopus embryos that contain both active and repressive histone modifications. Cayman's Histone H2A (Xenopus, recombinant) protein can be used as a substrate for enzyme activity assays, as well as for Western blot (WB) applications.Purity: >95% estimated by SDS-PAGE. Source: Recombinant histone H2A expressed in E. coli. Amino Acids: 2-130 (full length). MW: 13.9 kDa. Formulation: (Request formulation change), A lyophilized powder. UniProt Accession #: P06897.