GPIHBP1 (C-Fc) (recombinant human)

Protein Construction: Recombinant Human Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 is produced by our Mammalian expression system and the target gene encoding Thr22-Gly151 is expressed with a Fc tag at the C-terminus. Sequence: Thr22-Gly151. Fusion tag: C-Fc Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 50-65 kDa. Protein function: Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) is a member of the Ly6 family of proteins, binds LPL in the subendothelial spaces and transports it to the capillary lumen. GPIHBP1 is an important regulator of triglyceride metabolism by increasing the efficiency of lydrolysis by LPL and uptake of fatty acids. GPIHBP1 was positively correlated with LPL, and GPIHBP1 is a better marker for body weight decrease than LPL. Protein function: Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries. Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding (PubMed:27929370, PubMed:29899144). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:19304573, PubMed:21314738). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:17997385, PubMed:19304573). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. [The UniProt Consortium]