GITR (human):Fc (human) (rec., 3 x 50µg)

3 x 50 µg. Human GITR (amino acids 26-162) is fused at the C-terminus to the Fc portion of human IgG1. GITR (Glucocorticoid-induced TNF receptor) is the receptor for TNFSF18. It is involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T cell receptor-mediated cell death. GITR serves as a negative regulator for NK cell activation. It mediates NF-kappaB activation via the TRAF2/NIK pathway.