Endostatin Protein, Mouse, Recombinant (His)

Description: Endostatin, an endogenous nonâ??glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMPâ??2 and MMPâ??9, and cathepsins S, B and L. The Nâ??terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its antiâ??endothelial and antiâ??tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse Endostatin shares 96% aa sequence identity with rat and 85â??87% with human, bovine and equine Endostatin. It is predominantly expressed in liver, kidney, lung, skeletal muscle and testis. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis. It is also thought to downâ??regulate angiogenesis by blocking VEGFâ??induced endothelial cell migration. Endostatin may also be involved with downâ??regulation of angiogenesis after establishment of placental circulation in the pregnant uterus.