DR6 (mouse):Fc (human, rec.)

(3 x 50µg). Mouse DR6 (amino acids 42-348) is fused at the C-terminus to the Fc portion of human IgG1. Lyophilized. Contains PBS. DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.