DR6 (human):Fc (human) (rec, 3 x 50µg)

(3 x 50µg). The Fc portion of human IgG1 is fused to the C-terminus of human DR6 (amino acids 42-351). Lyophilized. Contains PBS. DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.