DPY-30 (human recombinant)

DPY-30 is a component of the MLL1 methylation complex, which interacts directly with Ash2L. In C. elegans, DPY-30 is required for dosage compensation in XX individuals, and its deletion or mutation is lethal. For XO individuals, DPY-30 is required for proper growth and development. DPY-30 is a homodimer in solution, and two monomers interact with one Ash2L monomer. Addition of DPY-30 to the MLL1, WDR5, RbBP5, and Ash2L complex results in a 2-fold increase in methylation rate, from 300x the MLL1 basal rate to 600x the MLL1 basal rate.Synonyms: DPY-30-like protein, hDPY-30, SAF19. Purity: >95%. Source: recombinant protein expressed in E. coli. Amino Acids: Amino Acids: 2-99 (full length). MW: 11.2 kDa. Formulation: (Request formulation change), 50 mM Tris, pH 8.0, 100 mM sodium chloride, and 20% glycerol. License: SUMOpro tag was used under non-exclusive license from LifeSensors, Inc.. UniProt Accession #: Q9C005.