DLC1 PrEST Antigen

PrEST Antigen DLC1, Gene description: DLC1 Rho GTPase activating protein, Alternative Gene Names: ARHGAP7, DLC-1, HP, p122-RhoGAP, STARD12, Antigen sequence: MVLLIMKLDQLDQDIENALSTSSSPSGTPTNLRRHVPDLESGSESGADTISVNQTRVNLSSDTESTDLPSSTPVANSGTKPKTTAIQGI, Storage: Upon delivery store at -20°C. Avoid repeated freeze/thaw cycles. Protein function: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. [The UniProt Consortium] Mouse gene identity: 79% Rat gene identity: 79%