D-Tyrosyl-tRNA Protein (recombinant human)

Protein Construction: Recombinant Human D-tyrosyl-tRNA(Tyr) deacylase 1 is produced by our Mammalian expression system and the target gene encoding Met1-Pro209 is expressed with a 6His tag at the C-terminus. Sequence: Met 1-Pro209. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 30 kDa. Protein function: D-tyrosyl-tRNA(Tyr) deacylase 1(DTD1) belongs to the DTD family, and expressed in many adult and fetal tissues such as testis, ovary, spleen in adult and fetal brain. It is a nucleus and cytoplasm located protein, and is preferentially phosphorylated in cells arrested early in S phase. DTD1 is an ATPase involved in DNA replication, it may facilitate loading of CDC45 onto pre-replication complexes. The protein may hydrolyze D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful effect of D-tyrosine. Protein function: Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034). [The UniProt Consortium]