Cynomolgus TfR (N-6His-Avi), biotinylated

Recombinant Cynomolgus Transferrin receptor protein 1 is produced by our Mammalian expression system and the target gene encoding Cys89-Phe760 is expressed with a 6His, Avi tag at the N-terminus. Protein function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway. [The UniProt Consortium]