CRTAM Protein, Mouse, Recombinant (His)

Description: Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNgamma by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile, therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. CRTAM Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 31.1 kDa and the accession number is Q149L7-1. References: Takeuchi A, et al. CRTAM confers late-stage activation of CD8 T cells to regulate retention within lymph node. J Immunol. 2009 Oct 1,183(7):4220-8. doi: 10.4049/jimmunol.0901248. Epub 2009 Sep 14. PMID: 19752223.