Concanavalin A

Concanavalin A is a plant lectin that has been found in jack bean (C. ensiformis) and is involved in plant defense. It is formed from the 290-amino acid precursor protein pro-concanavalin A via deglycosylation by N-glycanase, peptide cleavage, and re-ligation to form the mature 237-amino acid monomer, which oligomerizes to form a tetramer. Each concanavalin A monomer has a carbohydrate recognition domain, which binds to alpha-D-mannose, alpha-D-glucose, and beta-D-fructose, and a metal binding site that is involved in stability. Concanavalin A has diverse biological activities, including erythrocyte agglutination, mitogenic stimulation, and anticancer activity. It has been used in affinity purification of various glycoproteins, as well as to induce T cell activation in vitro and liver injury in experimental mouse models of autoimmune hepatitis.CAS Number: 11028-71-0. Synonyms: Con A. Formulation: (Request formulation change), A lyophilized powder. Solubility: DMSO: 5 mg/ml, PBS (pH 7.2): 10 mg/ml. Origin: Plant/Canavalia ensiformis.