Coiled-Coil Domain-Containing Protein 134/CCDC134 Protein(C-6His) (recombinant human)

Protein Construction: Recombinant Human Coiled-coil domain-containing protein 134 is produced by our Mammalian expression system and the target gene encoding Thr23-Leu229 is expressed with a 6His tag at the C-terminus. Sequence: Thr 23-Leu229. Fusion tag: C-6His Endotoxin: < 1.0 EU per µg as determined by the LAL method. Apparent Molecular Mass: 25 kDa. Protein function: Coiled-coil domain-containing protein 134(CCDC134), which is short for Coiled-coil domain-containing protein 134, belongs to the UPF0388 family. Human CCDC134 cDNA encodes a 229 amino acid (aa) precursor that contains a 22 aa signal peptide and a 207 aa with coiled-coil domain protein. Coiled-coil domain is a motif in which alpha-helix are coiled together. This protein is usually expressed in extracellular region. CCDC134 is also considered as a novel human MAPK-regulating protein that can inhibit the MAPK pathway. Protein function: In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). [The UniProt Consortium]