CD28 -muIg Fusion Protein, (human)

Human CD28 is an important costimulatory molecule found on all CD4 T cells and on about half of the CD8 cells. T cell activities attributed to CD28 include prevention of energy, induction of cytokine gene transcription, stabilization of cytokine mRNAs and activation of CD8 cytotoxic T lymphocytes. Monovalency of the CD28 receptor for its natural ligands is essential to provide costimulation without inducing responses in the absense of TCR engagement.