Canine ICAM-1/CD54 Protein

Recombinant Canine ICAM-1/CD54 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln25-Asn476. Intercellular adhesion molecule-1 (ICAM-1, CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis.