Cadherin-16 Extracellular Domain (human, recombinant)

Cadherin-16 (CDH16) is a cell adhesion molecule with roles in embryonic development and cell growth. It is composed of seven extracellular cadherin repeats, a transmembrane domain, and a short cytoplasmic domain. CDH16 is expressed primarily in renal and thyroid tissues and localized to the plasma membrane. It promotes the formation of renal tubuli and the development of thyroid follicles during development, and its expression persists at high levels in the adult kidney and follicular cells of the adult thyroid gland. Reduced kidney and thyroid levels of CDH16 are associated with the development of cancer in those tissues. Urinary levels of CDH16 are decreased in patients with sepsis-induced acute kidney injury. Cayman's Cadherin-16 Extracellular Domain (human, recombinant) protein can be used in binding assay and Western blot (WB) applications. This protein consists of 779 amino acids, has a calculated molecular weight of 84. kDa, and a predicted N-terminus of Lys19 after signal peptide cleavage.