Anti-ABHD10 (human, recombinant)

alpha/beta-Hydrolase domain-containing protein 10 (ABHD10) is an S-depalmitoylase, a deglucuronidase, and a member of the metabolic serine hydrolase family. It is composed of an N-terminal mitochondrial localization signal and ABHD fold that contains the Ser-His-Asp catalytic triad. ABHD10 is expressed in testis and liver and localizes to the mitochondria. It is involved in redox homeostasis via regulation of peroxiredoxin-5 (Prx5) palmitoylation and mitochondrial sheath formation via regulation of spermatogenesis-associated protein 19 (SPATA19), glycerol kinase 2 (GK2), and pyruvate dehydrogenase protein X component (PDHX) palmitoylation. ABHD10 is also involved in deglucuronidation of mycophenolic acid acyl glucuronide and probenecid acyl glucuronide in the liver. Knockout of Abhd10 induces sperm motility defects in mice. Liver expression of ABHD10 is decreased in patients with severe alcoholic hepatitis. Cayman's ABHD10 (human, recombinant) protein consists of 271 amino acids and has a calculated molecular weight of 30. kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 32 kDa.