Adiponectin, Recombinant, Rat (ACRP30, AdipoQ, apM1, GBP28, Adipocyte Complement Related Protein of

ACRP30 was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, ACRP30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased ACRP30 levels. Sequence: Rat adiponectin (aa16-244) is fused at the N-terminus to a FLAG(R)-tag. Molecular Weight: ~30kD (SDS-PAGE), Biological Activity: Induces the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.