ABHD14B (human, recombinant)

alpha/beta-Hydrolase domain-containing protein 14B (ABHD14B) is a lysine deacetylase and member of the metabolic serine hydrolase family. It is composed of an ABHD fold that contains the Ser-His-Asp catalytic triad. ABHD14B is expressed in kidney, liver, and lung and localizes to the cytosol and nucleus. It transfers an acetyl group from acetylated lysines on proteins, such as histones, to CoA to produce acetyl-CoA. ABHD14B is involved in the regulation of glycolysis and the citric acid cycle, as well as viral transcription from hepatitis B virus (HBV) covalently closed circular DNA (cccDNA). Decreased expression of ABHD14B is associated with poor prognosis in patients with breast cancer. Cayman's ABHD14B (human, recombinant) protein consists of 225 amino acids and has a calculated molecular weight of 24. kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 24 kDa.