ZNF207 (Vector pENTR223.1, Accession No. BC002372)

Length: 1392 Sequence: atgggtcgca agaagaagaa gcagctgaag ccgtggtgct ggtattgtaa tagagatttt gatgatgaga agatccttat tcagcaccaa aaagcaaagc attttaaatg ccatatatgt cacaagaaat tgtatacagg acctggctta gctattcatt gcatgcaggt acataaagaa acaatagatg ccgtaccaaa tgcaatacct ggaagaacag acatagagtt ggaaatatat ggtatggaag gtattccaga aaaagacatg gatgaaagac gacgacttct tgaacagaaa acacaagaaa gtcaaaaaaa gaagcaacaa gatgattctg atgaatatga tgatgacgac tctgcagcct caacttcatt tcagccacag cctgttcaac ctcagcaagg ttatattcct ccaatggcac agccaggact gccaccagta ccaggagcac caggaatgcc tccaggcata cctccattaa tgccaggtgt tcctcctctg atgccaggaa tgccaccagt tatgccaggc atgccacctg gattgcatca tcagagaaaa tacacccagt cattttgcgg tgaaaacata atgatgccaa tgggtggaat gatgccacct ggaccaggaa taccacctct gatgcctgga atgccaccag gtatgccccc acctgttcca cgtcctggaa ttcctccaat gactcaagca caggctgttt cagcgccagg tattcttaat agaccacctg caccaacagc aactgtacct gccccacagc ctccagttac taagcctctt ttccccagtg ctggacaggc tcaggcagct gtccaaggac ctgttggtac agatttcaaa cccttaaata gtacccctgc aacaactaca gaacccccaa agcctacatt ccctgcttat acacagtcta cagcttcaac aactagtaca acaaatagta ctgcagctaa accagcggct tcaataacaa gtaagcctgc tacacttaca acaactagtg caaccagtaa gttgatccat ccagatgagg atatatccct ggaagagaga agggcacagt tacctaagta tcaacgtaat cttcctcggc caggacaggc ccccatcggt aatccaccag ttggaccaat tggaggtatg atgccaccac agccaggcat cccacagcaa caaggaatga gacccccaat gccacctcat ggtcagtatg gtggtcatca tcaaggcatg ccaggatacc ttcctggtgc tatgcccccg tatgggcagg gaccgccaat ggtgccccct taccagggtg ggcctcctcg acctccgatg ggaatgagac ctcctgtaat gtcgcaaggt ggccgttact Protein function: Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low- complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). [The UniProt Consortium]