VAX2 (Vector pUC, Accession No. BC006336)

Length: 873 Sequence: atgggcgatg ggggcgccga gcgcgaccgg ggccccgcgc gccgggcgga gtctggtggc ggcggtgggc gctgcggaga ccgcagcgga gcgggggact tgcgagctga tggcggtggc cacagcccaa cggaggtggc cgggacctca gcctccagtc ccgcaggctc cagggagagt ggagccgaca gcgacgggca gcccgggccc ggcgaggcag accactgccg ccgcatactg gtgcgagatg ccaaagggac aattcgggaa attgtcctgc ctaagggcct ggacctggac cggcccaagc ggacacgtac atccttcact gccgagcagc tgtaccgcct ggagatggag ttccagcgct gccagtatgt ggtgggccgc gagcgcactg agctggcccg ccagctgaac ctctccgaga cccaggtgaa ggtctggttc cagaaccgcc gcaccaagca gaagaaagac cagagcagag acctggagaa gcgggcgtcc tcctcagcct ccgaggcctt tgccacctcc aacattctgc ggctgctgga gcagggccgg ctgctctctg tgcccagggc ccctagcctc ctggcgctga cccctagcct gccaggccta cctgccagcc acaggggcac ctccttaggt gaccccagga actcctcccc acgcctcaac ccgctgtcct cggcctcagc gtccccccca ctgccgcccc ctctgccagc tgtctgcttt tcctcggccc cgctcctgga tctgcctgcc ggctacgaac tgggttcctc ggccttcgag ccatacagct ggctagaacg gaaagtgggc agcgccagca gctgcaagaa agctaacact Protein function: Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina. [The UniProt Consortium]