TRIM7 (Vector pUC, Accession No. BC132863)

Length: 1536 Sequence: atggcggctg tgggaccgcg gaccggcccc ggaaccggcg ccgaggctct agcgctggcg gcagagctgc agggcgaggc gacgtgctcc atctgcctag agctctttcg tgagccggtg tccgtcgagt gcggccacag cttctgccgc gcctgcatag ggcgctgctg ggagcgcccg ggcgcggggt ctgttggggc cgccacccgc gcgcccccct tcccactgcc ctgtccgcag tgccgcgagc ccgcgcgccc cagtcagctg cggcccaacc ggcagctggc ggcagtggcc acgctcctgc ggcgcttcag cctgcccgcg gctgccccgg gagagcacgg gtctcaggcg gccgcggccc gggcagcggc tgcccgctgc gggcagcatg gcgaaccctt caagctctac tgccaggacg acggacgcgc catctgcgtg gtgtgcgacc gcgcccgcga gcaccgcgag cacgccgtgc tgccgctgga cgaggcggtg caggaggcca aggagctctt ggagtccagg ctgagggtct tgaagaagga actggaggac tgtgaggtgt tccggtccac ggaaaagaag gagagcaagg agctgctgaa acagatggca gcggagcagg agaaggtggg ggcagagttc caggcactga gggctttcct ggtggagcag gagggtcggc tgctaggccg cctggaggaa ctgtcccggg aggtggcaca gaagcagaat gagaacctgg cccagctcgg ggttgagatc acccagctgt ccaagctcag cagccagatc caggagacag ctcaaaagcc tgaccttgac tttctccagg aattcaaaag cacgctgagc aggtgtagca atgtgcctgg ccccaagcca accacagtct cttctgagat gaagaataaa gtctggaatg tttctctcaa gacctttgtc ttaaaaggga tgctgaagaa gttcaaagag gaccttcggg gagagctgga gaaagaggag aaagtggagc tcaccttgga tcccgacacg gccaacccgc gcctcatcct ctctctggat cttaagggcg tgcgcctcgg cgagcgggcc caggacctgc ccaaccaccc ctgccgcttc gacaccaaca cccgcgtcct ggcgtcctgc ggcttctcct cgggccggca tcactgggag gtggaggtgg gctctaagga cggctgggcc tttggcgtgg cccgcgagag cgtgcgccga aagggcctga cgcccttcac tcccgaggag ggcgtctggg ccctgcagct caacggcggc cagtactggg ccgtgaccag ccccgagcgg tcgcccctca gctgcgggca cctgtcgcgc gtgcgggtgg ccctggacct ggaggtggga gccgtgtcct tctacgctgt ggaggacatg cgccacctct acaccttccg cgtcaacttc caggagcgcg tgttcccgct tttctctgtt tgctccacgg gcacctactt gcgaatctgg Protein function: E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (PubMed:25851810). Promotes the TLR4-mediated signaling activation through its E3 ligase domain leading to production of proinflammatory cytokines and type I interferon. Plays also a negative role in the regulation of exogenous cytosolic DNA virus-triggered immune response. Mechanistically, enhances the 'Lys-48'-linked ubiquitination of STING1 leading to its proteasome-dependent degradation (PubMed:32126128). [The UniProt Consortium]