TIAM1 (Vector pUC, Accession No. BC117192)

Length: 4776 Sequence: atgggaaacg cagaaagtca acatgtagag cacgagtttt atggagaaaa gcatgccagc ctggggcgca agcacacttc ccgctccctg cgcctctcgc acaagacgcg gaggaccagg cacgcttcct cggggaaggt gatccacagg aactccgaag tgagcacccg atccagcagc acccccagca tcccccagtc cctggctgaa aatggcctgg agcccttctc ccaagatggt accctagaag acttcgggag ccccatctgg gtggaccgag tggacatggg cttgagacct gtgtcttaca ctgactcttc tgtcactccc agcgtagaca gcagcatcgt cctcacagca gcctctgtgc agagcatgcc agacactgag gagagcaggc tttacgggga tgacgctaca tatttggctg agggaggcag gaggcagcat tcctatacat ccaatgggcc cactttcatg gagacggcga gctttaagaa gaaacgctcc aaatctgcag acatctggcg ggaggacagc ctggaattct cactctctga tctgagccaa gaacatttaa caagcaacga agaaatcttg ggttccgccg aagagaagga ctgcgaggag gctcggggga tggaaacgcg ggcgagtccg cggcagctca gcacctgtca gagagccaat tccttgggtg acttgtatgc tcagaaaaac tctggagtga cagcaaacgg ggggccgggg agcaaatttg caggctactg tcggaatttg gtgtctgata ttcccaatct tgcaaaccat aagatgccac cagctgctgc tgaagagact cctccgtaca gtaattataa cacacttccc tgtaggaaat ctcactgtct ctctgaaggt gccaccaacc cacaaattag ccatagcaac agcatgcaag gcagaagagc taaaacaact caggatgtta atgcaggcga gggcagtgag tttgcagaca gtgggattga aggggccact accgacacgg acctcctgtc caggcgatct aatgccacca actccagcta ctcacccacc acaggccggg cctttgtggg cagcgacagc ggcagcagct ccaccgggga tgcggctcgt cagggggtgt acgagaactt ccggcgggag ctggagatga gcaccaccaa cagcgagagc ctggaggagg ccggctcggc gcacagcgat gagcagagca gcggcaccct gagctctccg ggccagtcgg acatcctgct gaccgccgca cagggcacgg tgcgcaaggc cggcgccctg gccgtcaaga acttcctggt gcacaagaag aacaagaagg tggagtcagc cacccggagg aagtggaagc actactgggt gtccctgaaa ggatgcacgc tatttttcta cgagagcgac ggcaggtctg ggatagacca caacagcatc cccaaacacg ccgtctgggt ggagaacagc attgtgcagg cggtgcctga gcaccccaag aaggactttg tcttctgcct cagcaattcc ctgggtgatg ccttcctttt tcagaccact agccagacgg agcttgaaaa ctggatcacc gccatccact ctgcctgcgc cactgcggtc gcgaggcacc accacaagga agacacgctc cgactcctga aatcagagat caaaaaactg gaacagaaga ttgacatgga tgaaaagatg aagaaaatgg gtgaaatgca gctgtcttca gtcactgact caaagaaaaa gaaaacaata ttagatcaga tctttgtctg ggagcaaaat ctcgagcagt tccaaatgga cctgtttcgt ttccgctgtt atttagccag ccttcagggt ggggagctgc caaaccccaa aaggcttctc gcttttgcaa gtcgaccaac gaaagtggcc atgggccgcc ttggaatctt ttcggtatca tcgtttcatg ccctggtggc agcacgcact ggtgaaactg gagtgagaag acgtactcag gccatgtcca gatccgcgag caagcgaagg agcaggtttt cttctctgtg gggtctggat actacctcca aaaagaagca gggacggcca agcatcaatc aggtgtttgg agagggaacc gaagctgtaa agaaatcttt agagggaata tttgatgaca ttgttccaga tggcaagagg gagaaagaag tggtcttacc taacgttcac cagcacaacc ctgactgcga catttgggtc cacgagtatt tcactccatc ctggttctgt ctgcccaata atcagcctgc cctgacggtc gtccggccag gcgacactgc acgggacacc ctggagctga tttgcaagac acatcaactg gatcattctg ctcattacct gcgcctgaaa tttctaatag aaaacaaaat gcagctctat gttccacagc ccgaggaaga catctatgag ctgctgtaca aagaaattga aatctgtcca aaagtcactc agagcatcca cattgagaag tcagatacag ctgctgatac ttacgggttt tcactttctt ctgtggaaga agatggtatt cgaaggctgt acgtgaatag tgtgaaggaa accggtttag cttccaagaa aggcctgaaa gcaggagatg agattcttga gatcaataat cgtgctgctg acgccctgaa ctcttctatg ctcaaagatt tcctctcaca gccctcgctg ggcctcctgg tgaggaccta ccccgagctg gaggaaggag tggagctgct ggaaagcccg ccccaccgag tggacggccc tgccgacctt ggcgagagcc ccctcgcctt tctcaccagc aacccagggc acagcctttg cagcgagcag ggcagcagtg ctgagaccgc tccagaggag accgaggggc cagacttgga atcctcagat gagactgatc acagcagcaa gagtacagaa caggtggccg cattttgccg cagtttgcat gagatgaacc cctctgacca gagcccatct cctcaggact ccacggggcc tcagctggcg accatgagac aactctcgga tgcagataag ctgcgcaagg tgatctgcga gctcctggag acggagcgca cctacgtgaa ggatttaaac tgtcttatgg agagatacct aaagcctctt caaaaagaaa cttttctcac ccaggatgag cttgacgtgc tttttggaaa tttaacggaa atggtagagt ttcaagtaga attccttaaa actctagaag atggagtgag actggtacct gatttggaaa agcttgagaa ggttgatcaa tttaagaaag tgctgttctc tctgggggga tcattcctgt attatgctga ccgcttcaag ctctacagtg ccttctgcgc cagccacaca aaagttccca aggtcctggt gaaagccaag acagacacgg ctttcaaggc attcttggat gcccagaacc cgaagcagca gcactcatcc acgctggagt cgtacctcat caagcccatc cagaggatcc tcaagtaccc acttctgctc agggagctgt tcgccctgac cgatgcggag agcgaggagc actaccacct ggacgtggcc atcaagacca tgaacaaggt tgccagtcac atcaatgaga tgcagaaaat ccatgaagag tttggggctg tgtttgacca gctgattgct gaacagactg gtgagaaaaa agaggttgca gatctgagca tgggagacct gcttttgcac actaccgtga tctggctgaa cccgccggcc tcgctgggca agtggaaaaa ggaaccagag ttggcagcat tcgtcttcaa aactgctgtg gtccttgtgt ataaagatgg ttccaaacag aagaagaaac ttgtaggatc tcacaggctt tccatttatg aggactggga ccccttcaga tttcgacaca tgatccccac ggaagcgctg caggttcgag ctttggcgag tgcagatgca gaggcaaatg ccgtgtgtga aattgtccat gtaaaatccg agtctgaagg gaggccggag agggtctttc acttgtgctg cagctcccca gagagccgaa aggatttcct aaaggctgtg cattcaatcc tgcgtgataa gcacagaaga cagctcctca aaaccgagag ccttccctca tcccagcaat atgtcccttt tggaggcaaa agattgtgtg cactgaaggg ggccaggccg gccatgagca gggcagtgtc tgccccaagc aagtctcttg ggaggaggag gcggcggctg gctcgaaaca ggtttaccat tgattctgat gccgtctccg caagcagccc ggagaaagag tcccagcagc cccccggtgg tggggacact gaccgatggg tagaggagca gtttgatctt gctcagtatg aggagcaaga tgacatcaag gagacagaca tcctcagtga cgatgatgag ttctgtgagt ccgtgaaggg tgcctcagtg gacagagacc tgcaggagcg gcttcaggcc acctccatca gtcagcggga aagaggccgg aaaaccctgg atagtcacgc gtcccgcatg gcacagctca agaagcaagc tgccctgtcg gggatcaatg gaggcctgga gagcgcaagc gaggaagtca tttgggttag gcgtgaagac tttgccccct ccaggaaact gaacactgag Protein function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration. [The UniProt Consortium]