THAP1 (Vector pENTR223.1, Accession No. BC021721)

Length: 642 Sequence: atggtgcagt cctgctccgc ctacggctgc aagaaccgct acgacaagga caagcccgtt tctttccaca agtttcctct tactcgaccc agtctttgta aagaatggga ggcagctgtc agaagaaaaa actttaaacc caccaagtat agcagtattt gttcagagca ctttactcca gactgcttta agagagagtg caacaacaag ttactgaaag agaatgctgt gcccacaata tttctttgta ctgagccaca tgacaagaaa gaagatcttc tggagccaca ggaacagctt cccccacctc ctttaccgcc tcctgtttcc caggttgatg ctgctattgg attactaatg ccgcctcttc agacccctgt taatctctca gttttctgtg accacaacta tactgtggag gatacaatgc accagcggaa aaggattcat cagctagaac agcaagttga aaaactcaga aagaagctca agaccgcaca gcagcgatgc agaaggcaag aacggcagct tgaaaaatta aaggaggttg ttcacttcca gaaagagaaa gacgacgtat cagaaagagg ttatgtgatt ctaccaaatg actactttga aatagttgaa gtaccagcat Protein function: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum- withdrawal and TNF-induced apoptosis. [The UniProt Consortium]