TDRD1 (Vector pUC, Accession No. BC063133)

Length: 3138 Sequence: atgacagagc catttaattt tgagaaaaat gaaaacaagc ttccaccaca tgagtcttta agaagtcctg gaacacttcc taaccaccct aatttcaggc tgaaaagctc agagaatgga aataaaaaga acaatttttt gctttgtgag caaaccaaac aatatttggc tagtcaggaa gacaattcag tttcttcaaa cccgaatggc atcaacggag aagtagttgg ctccaaagga gacaggaaaa aattgccagc aggaaactca gtgtcaccac caagtgctga aagtaattca ccacccaaag aagtgaatat taagcctgga aataatgtac gtcctgcaaa atcaaaaaaa ctaaacaagt tggtcgagaa ttccttgtcc ataagtaatc cagggctctt cacctcctta ggacctcctc ttcggtccac aacttgccat cgctgtggcc tatttggatc gctgaggtgc tctcagtgca agcagaccta ctattgctcc acagcatgtc aaagaagaga ctggtctgca cacagcatcg tgtgcaggcc tgttcagcca aatttccaca aacttgaaaa taaatcatct attgaaacaa aggatgtgga ggtaaacaat aagagtgact gtccacttgg agttactaag gaaatagcca tttgggctga gagaataatg ttttctgatt tgagaagtct acaactcaag aaaaccatgg aaataaaggg tacggttacc gaattcaaac acccagggga cttctacgtg cagttatatt cttcagaagt tttagaatac atgaaccaac tctctgccag cttaaaagaa acatatgcaa atgtgcatga aaaagactat attcctgtta agggggaagt ttgtattgcc aagtacactg ttgatcagac ctggaacaga gcaatcatac aaaacgttga tgtgcagcaa aagaaggcac atgtcttata tattgattat ggaaatgaag aaataattcc attaaacaga atttaccacc tcaacaggaa cattgacttg tttcctcctt gtgccataaa gtgctttgta gccaatgtta tcccagcaga agggaattgg agcagtgatt gtatcaaagc tactaaacca ctgttaatgg agcagtactg ctccataaag attgtcgaca tcttggaaga ggaagtggtt acctttgctg tagaagttga gctgccaaat tcaggaaaac ttttagacca tgtgcttata gaaatgggat atggcttgaa acccagtgga caagattcta agaaggaaaa tgcagatcaa agtgatcctg aagatgttgg aaaaatgaca actgaaaaca acattgtcgt agacaaaagt gacctaatcc caaaagtgtt aactttgaat gtaggtgatg agttttgtgg tgtggttgcc cacattcaaa caccagaaga cttcttttgt caacaactgc aaagtggccg aaagcttgct gaacttcagg catcccttag caagtactgt gatcagttgc ctccacgctc tgatttttat ccagccattg gtgatatatg ttgtgctcag ttctcaggag taaagccatc attaggaatt tggactccag aagctatttg tctcatgaaa aaacttgtac agaacaaaat aatcacagtg aaagtggtgg acaagttgga aaacagttcc ctggtggagc ttattgataa atccgagacg cctcatgtca gtgttagcaa agttctccta gatgcaggct ttgctgtggg agaacagagt atggtgacag ataaacccag tgacgtgaaa gaaaccagtg ttcccttggg tgtggaagga aaagtaaatc cattggagtg gacatgggtt gaacttggtg ttgaccaaac agtagatgtt gtggtctgtg tgatatatag tcctggagaa ttttattgcc atgtgcttaa agaggatgct ttaaagaaac tcaatgattt gaacaagtca ttagcagaac actgccagca gaagttacct aatggtttca aggcagagat aggacaacct tgttgtgctt tttttgcaga tatacagtct agaaacaaac attggtctga agaagccata acaagattcc agatgtgtgt tgctgggata aaattgcaag ccagagtggt tgaagtcact gaaaatggga taggagttga actcaccgat ctctccactt gttatcccag aataattagt gatgttctga ttgatgaaca tctggtttta aaatctgctt caccacataa agacttacca aatgacagac ttgttaataa acatgagctt caagttcatg tacagggact tcaagctacc tcttcagctg agcaatggaa gacgatagaa ttgccagtgg ataaaactat acaagcaaat gtattagaaa tcataagccc aaacttgttt tatgctctac caaaagggat gccagaaaat caggaaaagc tgtgcatgtt gacagctgaa ttattagaat actgcaatgc tccgaaaagt cgaccaccct atagaccaag aattggagac gcatgctgtg ccaaatacac aagtgatgat ttttggtatc gtgcagttgt tctggggaca tcagacactg atgtggaagt gctctatgca gactatggaa acattgaaac cctgcctctt tgcagagtgc aaccaatcac ctctagccac ctggcgcttc ctttccaaat tattagatgt tcacttgaag gattaatgga attgaatgga agctcttctc aattaataat aatgctatta aaaaatttca tgttgaatca gaatgtaatg ctttctgtga aaggaattac aaagaatgtc catacagtgt cagttgagaa atgttctgag aatgggactg tcgatgtagc tgataagcta gtgacatttg gtctggcaaa aaacatcaca cctcaaaggc agagtgcttt aaatacagaa aagatgtata ggatgaattg ctgctgcaca gagttacaga aacaagttga aaaacatgaa catattcttc tcttcctctt aaacaattca accaatcaaa ataaatttat tgaaatgaaa aaactgttaa Protein function: Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins. [The UniProt Consortium]