STIL (Vector pUC, Accession No. BC126223)

Length: 3864 Sequence: atggagccta tatatccttt tgcacggccc cagatgaata ccaggtttcc ttcaagcagg atggtacctt tccactttcc tccatcaaaa tgtgcacttt ggaacccaac gccaactgga gatttcatct acttacatct cagttactac agaaatccaa agcttgtggt gactgagaag accatccgac ttgcttatcg tcatgctaag cagaataaaa aaaattcgtc atgcttttta cttggttctc tgacagcaga cgaagatgaa gaaggtgtaa cattgacagt agatcgcttt gatcctggtc gagaagtacc tgaatgccta gaaataaccc ctactgcttc tcttcctggg gactttttga ttccatgcaa agttcatact caagaacttt gttcaagaga aatgatagtt cacagtgtag atgacttcag ttcagcttta aaggctctac agtgccatat atgtagcaaa gattccttgg actgtggtaa gctgctttcc ctaagagttc atatcacttc cagggagagt ttggacagtg tggaatttga cttgcattgg gcagcagtaa ctctagcaaa taactttaaa tgcacacctg tgaagcccat ccccattatt ccaacagctc tggcaagaaa cttgagcagt aatctgaata tttctcaagt tcaagggact tataaatatg gatatcttac catggatgaa acacgcaaat tgttactttt gttggaatct gatcccaagg tttattctct accattggtg ggaatttggc tgtctggaat tacacatatc tatagtcctc aggtatgggc ttgctgtttg cgatacatat tcaattcttc tgttcaagaa agggtttttt cagaatctgg aaatttcatc atagttctct attctatgac acataaggaa cctgagtttt atgaatgctt cccttgtgat ggcaagatac ctgactttcg gtttcagttg ctaaccagta aggaaacatt acatcttttc aaaaatgttg aacctcctga caaaaatcca atccgttgtg aactgagcgc tgaaagccaa aatgcagaaa cagagttttt cagtaaggct tccaagaatt tttcaattaa gaggtcttcc caaaagttat cttctgggaa gatgccaata catgatcacg actctggtgt tgaagatgaa gatttttctc caagaccaat tcctagtcct catccagtga gtcagaagat ttctaagatc caaccatcag ttcctgaact ttcacttgtg ttggatggca atttcataga atcaaaccct ctgcctactc cattggaaat ggtgaataat gaaaatcctc ctttgattaa ccacttggaa cacttgaagc cattgcaacc ccagctttat gatgagaaac acagtccaga agttgaagct ggagagcctt ccttgagagg aataccaaat cagttaaacc aggataaacc agctcttttg agacactgca aagtaagaca gccacctgcc tataagaaag ggaaccccca taccaggaac agtattaaac catcttctca taatgggcca tctcatgata tatttgaaaa gctccaaaca gtttctgctg gaaatgtaca aaacgaagag tatcctataa gaccctccac acttaattct aggcagtctt ctcttgcccc gcagtcccaa ccacacgatt ttgttttttc accccataat tcaggaagac caatggaact tcagatacct actcccccac tgccatctta ctgttccaca aacgtttgca ggtgttgtca gcatcatagt catattcaat atagtccgct aaattcttgg caaggagcaa acacagttgg atccattcaa gatgtccagt ctgaagccct tcaaaagcat tcattatttc acccaagtgg atgtccagcc ctgtactgta atgcattctg ttcttcaagt agtcctatag ccttgagacc tcagggagat atgggcagtt gttctcccca cagcaatatt gaaccatcgc ctgtggcaag accgccttca catatggact tatgtaaccc acagccttgc acagtgtgca tgcacacacc caagactgag tcagataatg gaatgatggg actatctcca gatgcatatc ggttcctcac agaacaagac agacagctaa gactacttca ggcacagatt cagcgtttgt tggaagcaca gtctctgatg ccctgttccc ctaagacaac tgctgttgaa gacacagtgc aagctggaag acaaatggag ttggtttctg tggaagcaca gtcttcccct ggcttgcaca tgagaaaagg tgtaagcatt gctgtgagca caggtgctag cttgttttgg aatgcagcag gtgaggatca agagcctgac tctcaaatga agcaagatga taccaaaatt tccagtgagg acatgaattt ttctgtcgat attaataatg aagtcacaag tcttccaggt agtgcatctt cattaaaagc agttgatatt cccagttttg aagagagcaa cattgctgtg gaagaagaat ttaaccagcc actttctgta tccaactctt ctctagttgt gagaaaagaa cctgatgtac ctgtgttctt tccaagtggc cagctggcag aaagtgtaag catgtgttta cagactggac caacaggggg tgccagtaac aattctgaaa catcagagga accaaaaatt gagcatgtaa tgcaaccctt gcttcatcaa ccatcagata accagaaaat ttaccaggat ttattgggtc aagtaaacca cctattaaat agttcctcca aggaaactga gcagccgtct accaaagcag taattatcag tcatgaatgc accagaaccc aaaacgttta ccatacaaag aaaaaaacac atcattcaag actggtggac aaagattgtg tccttaatgc aactcttaag caactaagaa gccttggagt aaaaattgat tctcccacta aagtgaagaa aaatgcacat aacgtggatc acgccagtgt gttggcatgc atcagcccag aagcagtgat ctctggatta aactgcatgt catttgctaa tgttggcatg agcggcttaa gccccaatgg tgtggatttg agcatggagg caaatgctat agctctgaaa tatttaaatg aaaatcagct gtcacaactg tctgtcactc gatcgaacca aaataattgt gacccattca gccttctcca tattaataca gacagaagca cagtggggct tagtttaatt tcaccaaaca acatgtcatt tgcaaccaaa aaatatatga agagatatgg actcctacaa agcagtgaca atagtgaaga tgaagaggaa cctcccgaca atgcagatag caagagtgaa tatttattga atcagaacct taggtccata cccgaacagc ttggtggtca gaaagagcct tctaagaatg accatgaaat aattaattgt tctaactgtg aatctgtggg gaccaacgca gatacgccag tattgagaaa tattacaaat gaagttttgc agacaaaagc aaaacagcag ttgactgaaa agccagcttt cttagtaaag aaccttaaac caagtcctgc agtgaacctt cgaaccggga aagcagagtt cactcaacat cctgagaaag aaaatgaagg ggacattaca atttttcctg aaagtttgca accttctgaa acgctaaagc agatgaatag catgaattca gtaggcacct tcttagatgt aaaacgtctc agacagttac caaaattatt Protein function: Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation, its long- term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). [The UniProt Consortium]