SPOCD1 (Vector pUC, Accession No. BC114430)

Length: 3612 Sequence: ATGTCCCAGG CGGGGGACGT AGAAGGCCCC AGCACAGGAG ACCCTGTGCT CAGTCCCCAA CACAACTGTG AGCTTTTACA GAACATGGAA GGAGCCAGCT CCATGCCAGG CCTGTCACCA GATGGGCCGG GAGCAAGCTC TGGGCCCGGA GTCAGGGCTG GCAGCAGAAG GAAGATCCCC AGGAAGGAGG CCCTTCGAGG TGGCAGCTCC CGGGCTGCAG GTGCTGCTGA GGTCCGGCCA GGGGTCTTGG AGCTGCTAGC TGTGGTACAG AGCCGGGGCT CGATGCTGGC TCCTGGGCTC CACATGCAGC TGCCCTCGGT GCCTGCTCAG GGGAGAGCTC TGACCTCCAA GAGGCTCCAG GTTTCTCTGT GTGACATCTT AGATGACAGT TGCCCCAGGA AACTTTGTAG CAGGTCTGCT GGCCTCCCAG AGAGAGCTCT GGCCTGCAGG GAGAGGCTTG CAGGAGTGGA GGAGGTGAGC TGCCTCAGGC CCAGGGAGGC CAGAGACGGT GGAATGAGTT CTCCAGGGTG TGACAGAAGA AGCCCCACAC TCAGCAAAGA GGAGCCCCCT GGAAGGCCCC TGACATCCTC ACCAGACCCA GTCCCTGTGA GGGTAAGAAA GAAATGGAGG AGGCAAGGGG CTCATTCAGA GTGTGAGGAA GGGGCTGGTG ACTTCCTGTG GCTTGATCAG AGCCCTCGTG GGGACAACCT CCTGTCTGTG GGAGACCCTC CCCAAGTTGC TGACCTGGAG TCCTTGGGAG GCCCTTGCAG ACCTCCCTCT CCAAAAGACA CTGGGTCTGG GCCTGGAGAG CCAGGTGGAA GTGGGGCAGG ATGTGCCTCA GGGACTGAGA AATTTGGATA TTTGCCCGCT ACAGGGGATG GGCCCCAGCC AGGCAGCCCC TGTGGCCCTG TCGGGTTCCC AGTGCCCAGT GGAGGGGAGT CCCTCAGTTC AGCTGCACAG GCTCCTCCAC AGAGCGCAGC ACTGTGCCTG GGGGCGTCAG CACAGGCCTC TGCAGAGCAG CAAGAAGCTG TGTGTGTCGT GCGGACTGGC AGCGATGAAG GCCAGGCTCC AGCACAGGAC CAGGAGGAGC TGGAGGCCAA GGCTCAGCCA GCTTCCAGGG GAAGGCTGGA GCAAGGACTC GCTGCCCCCG CTGACACCTG TGCCAGCTCC CGGGAGCCCT TGGGCGGCCT CAGCTCCTCC CTGGATACTG AAGCCAGCAG GGCCTGCTCA GGCCCATTCA TGGAGCAGAG AAGATCCAAG GGCACTAAGA ACCTGAAGAA AGGTCCAGTG CCCTGTGCCC AAGACCGGGG CACAGACAGA AGCTCAGACA ACTCCCACCA GGACAGGCCA GAGGAACCCA GCCCAGGAGG CTGCCCCAGA CTGGAGGAAG TGAAAATACC CCATGGAGTG AAGCTTGTGT GCTACCTGGG TTCCGGGCCA GTGATCCAGC TCCTGGGGGC CATCAGCCAC GGCCAGGCAG GGGGGCAGCT GCCACCAAAG CTGGAGGTTC TAGAGGACTT GATGGAGGTC AGCTCACCCT CACCTGCCCA GAGGCTCAGA AGGAAGAAAA GGCCCATGGT GCAGGGCCCT GCTGGGTGCC AGGTTTTCCA GCCTTCTCCT TCAGGAGGCA CAGCAGGGGA CCCTGGTGGC CTCTCTGACC CCTTCTACCC TCCAAGAAGC GGTTCCCTGG CCCTTGGCGA CCCCAGCTCG GACCCTGCAT GTTCCCAGAG TGGCCCAATG GAGGCTGAAG AGGATTCTCT TCCGGAGCAG CCAGAGGACT CAGCTCAGCT CCAACAGGAG AAGCCATCCC TGTATATTGG GGTGCGGGGC ACTGTTGTCC GTTCCATGCA GGAGGTACTA TGGACTCGCC TTCGGGAGCT CCCAGACCCA GTGCTGAGTG AGGAGGTGGT GGAGGGCATT GCTGCTGGCA TTGAGGCAGC CCTCTGGGAC CTGACACAAG GCACCAATGG CCGGTACAAG ACCAAGTATC GCAGCCTGCT GTTCAACCTG CGGGACCCCA GGAACCTGGA CTTGTTTCTC AAAGTGGTTC ATGGAGATGT CACCCCCTAC GACCTGGTGC GGATGAGCTC GATGCAGCTG GCCCCCCAGG AGCTGGCCCG CTGGCGGGAC CAGGAGGAGA AAAGGGGCCT GAATATCATT GAGCAGCAAC AGAAGGAGCC GTGCAGACTT CCAGCCTCCA AAATGACCCA CAAGGGCGAA GTGGAGATTC AGCGGGACAT GGACCAGACA CTGACCCTGG AGGATCTGGT GGGACCGCAG ATGTTCATGG ACTGCAGCCC ACAGGCCCTG CCCATCGCAT CAGAGGACAC CACGGGGCAG CATGACCACC ACTTCTTAGA CCCCAACTGC CACATCTGCA AGGACTGGGA GCCCTCGAAT GAGCTGCTAG GCTCCTTCGA AGCCGCCAAG AGCTGCGGGG ACAATATCTT CCAGAAAGCC CTAAGCCAAA CTCCTATGCC TGCTCCAGAG ATGCCCAAAA CCAGGGAGTT GTCTCCCACG GAACCACAGG ACAGGGTCCC TCCATCTGGG CTCCATGTGC CTGCTGCACC CACAAAGGCC CTGCCCTGCC TGCCACCCTG GGAAGGTGTT CTGGACATGT TCTCCATCAA GCGGTTCCGG GCCAGGGCCC AGCTGGTCTC GGGACACAGC TGTCGGCTTG TCCAGGCTCT GCCCACCGTG ATCCGCTCGG CAGGCTGCAT CCCCTCCAAC ATTGTCTGGG ACCTTCTGGC CAGCATCTGC CCAGCCAAGG CCAAGGACGT CTGCGTGGTC AGACTGTGCC CACATGGGGC CCGGGACACC CAGAACTGCC GCCTGCTCTA CTCATACCTC AATGATAGGC AGCGCCACGG GCTGGCCTCT GTGGAGCACA TGGGGATGGT CCTGCTGCCC CTGCCTGCCT TCCAGCCCCT GCCCACCAGG CTGCGCCCTT TGGGGGGCCC AGGTCTGGAG GTCACTCACT CAAGTCTGTT GCTGGCTGTG CTGCTCCCCA AGGAAGGGCT TCCAGACACA GCAGGGTCCA GCCCCTGGTT GGGGAAGGTT CAAAAGATGG TCTCCTTCAA CAGTAAGGTG GAGAAGAGAT ACTATCAGCC AGATGACAGG AGGCCGAATG TGCCCCTGAA GGGCACCCCT CCCCCAGGAG GTGCCTGGCA GCAGAGCCAG GGCAGGGGCA GTATAGCTCC AAGGGGAATC TCTGCTTGGC AGAGGCCCCC CAGAGGCAGG GGGAGGCTCT GGCCAGAGCC TGAAAACTGG CAGCATCCTG GGCGAGGGCA GTGGCCCCCA GAGCCAGGCT TGCGCCAGTC CCAGCATCCC TATTCAGTAG CACCAGCTGG TCATGGCTTT GGCCGTGGCC AGCACTTCCA CAGGGACTCC TGTCCCCACC AAGCCCTGCT CCGGCACCTC GAATCCCTGG CGACCATGAG TCACCAGCTC CAAGCCTTAC TGTGCCCCCA GACCAAGAGC TCCATCCCCC GCCCTCTGCA GCGTTTGTCT AGCGCCCTTG CAGCTCCAGA GCCCCCTGGC CCAGCCCGTG ACTCCTCTTT GGGGCCTACA GATGAAGCTG GCTCTGAGTG TCCCTTCCCT AGAAAGGCCT Protein function: Essential excecutor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells. Associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes. Tethering of PIWIL4 to a nascent transposable element transcript recruits repressive chromatin remodeling activities and the de novo methylation apparatus through SPOCD1. Not required for piRNA biosynthesis. [The UniProt Consortium]