SLC38A9 (Vector pUC, Accession No. BC066891)

Length: 1686 Sequence: ATGGCAAATA TGAATAGTGA TTCTAGGCAT CTTGGCACCT CTGAGGTAGA TCATGAAAGA GATCCTGGAC CTATGAATAT CCAGTTTGAG CCATCGGATC TAAGATCCAA AAGGCCTTTC TGTATAGAGC CCACAAACAT CGTGAATGTG AATCATGTCA TTCAGAGGGT TAGTGACCAT GCCTCTGCCA TGAACAAGAG AATTCATTAC TACAGCCGGC TCACCACTCC TGCAGACAAG GCACTGATTC CCCCAGACCA TGTAGTTCCA GCTCCAGAAG AGTGCTATGT GTATAGTCCA TTGGGCTCTG CTTATAAACT TCAAAGTTAC ACTGAAGGAT ACGGTAAAAA CACCAGTTTA GTAACCATTT TTATGATTTG GAATACCATG ATGGGAACAT CTATACTAAG CATTCCTTGG GGCATAAAAC AGGCTGGATT TACTACTGGA ATGTGTGTCA TCATACTGAT GGGCCTTTTA ACACTTTATT GCTGCTACAG AGTAGTGAAA TCACGGACTA TGATGTTTTC GTTGGATACC ACTAGCTGGG AATATCCAGA TGTCTGCAGA CATTATTTCG GCTCCTTTGG GCAGTGGTCG AGTCTCCTTT TCTCCTTGGT GTCTCTCATT GGAGCAATGA TAGTTTATTG GGTGCTTATG TCAAATTTTC TTTTTAATAC TGGAAAGTTT ATTTTTAATT TTATTCATCA CATTAATGAC ACAGACACTA TACTGAGTAC CAATAATAGC AACCCTGTGA TTTGTCCAAG TGCCGGGAGT GGAGGCCATC CTGACAACAG CTCTATGATT TTCTATGCCA ATGACACAGG AGCCCAACAG TTTGAAAAGT GGTGGGATAA GTCCAGGACA GTCCCCTTTT ATCTTGTAGG GCTCCTCCTC CCACTGCTCA ATTTCAAGTC TCCTTCATTT TTTTCAAAAT TTAATATCCT AGGCACAGTG TCTGTCCTTT ATTTGATTTT CCTTGTCACC TTTAAGGCTG TTCGCTTGGG ATTTCATTTG GAATTTCATT GGTTTATACC AACAGAATTT TTTGTACCAG AGATAAGATT TCAGTTTCCA CAGCTGACTG GAGTGCTTAC CCTTGCTTTT TTTATTCATA ATTGTATCAT CACACTCTTG AAGAACAACA AGAAACAAGA AAACAATGTG AGGGACTTGT GCATTGCTTA TATGCTGGTG ACATTAACTT ATCTCTATAT TGGAGTCCTG GTTTTTGCTT CATTTCCTTC ACCACCATTA TCCAAAGATT GTATTGAGCA GAATTTTTTA GACAACTTCC CTAGCAGTGA CACCCTGTCC TTCATTGCAA GGATATTCCT GCTGTTCCAG ATGATGACTG TATACCCACT CTTAGGCTAC CTGGCTCGTG TCCAGCTTTT GGGCCATATC TTCGGTGACA TTTATCCTAG CATTTTCCAT GTGCTGATTC TTAATCTAAT TATTGTGGGA GCTGGAGTGA TCATGGCCTG TTTCTACCCA AACATAGGAG GGATCATAAG ATATTCAGGA GCAGCATGTG GACTGGCCTT TGTATTCATA TACCCATCTC TCATCTATAT AATTTCCCTC CACCAAGAAG AGCGTCTGAC ATGGCCTAAA TTAATCTTCC ACGTTTTCAT CATCATTTTG GGCGTGGCTA ACCTGATTGT TCAGTTTTTT Protein function: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25561175, PubMed:25567906, PubMed:29053970). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids (PubMed:25561175, PubMed:25567906). Acts as an arginine sensor (PubMed:25567906, PubMed:29053970). Following activation by arginine binding, mediates transport of leucine, tyrosine and phenylalanine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation (PubMed:29053970). [The UniProt Consortium]