SLC11A1 (Vector pUC, Accession No. BC071165)

Length: 1299 Sequence: atggtgcgat gtcagctcac tgcaacctct acctcccagg tgccccgcac cgtcctctgg ctgaccatcg agctagccat tgtgggctcc gacatgcagg aagtcatcgg cacggccatt gcattcaatc tgctctcagc tggacgaatc ccactctggg gtggcgtcct catcaccatc gtggacacct tcttcttcct cttcctcgat aactacgggc tgcggaagct ggaagctttt tttggactcc ttataaccat tatggccttg acctttggct atgagtatgt ggtggcgcgt cctgagcagg gagcgcttct tcggggcctg ttcctgccct cgtgcccggg ctgcggccac cccgagctgc tgcaggcggt gggcattgtt ggcgccatca tcatgcccca caacatctac ctgcactcgg ccctggtcaa gtctcgagag atagaccggg cccgccgagc ggacatcaga gaagccaaca tgtacttcct gattgaggcc accatcgccc tgtccgtctc ctttatcatc aacctctttg tcatggctgt ctttgggcag gccttctacc agaaaaccaa ccaggctgcg ttcaacatct gtgccaacag cagcctccac gactacgcca agatcttccc catgaacaac gccaccgtgg ccgtggacat ttaccagggg ggcgtgatcc tgggctgcct gttcggcccc gcggccctct acatctgggc cataggtctc ctggcggctg ggcagagctc caccatgacg ggcacctacg cgggacagtt cgtgatggag ggcttcctga ggctgcggtg gtcacgcttc gcccgtgtcc tcctcacccg ctcctgcgcc atcctgccca ccgtgctcgt ggctgtcttc cgggacctga gggacttgtc gggcctcaat gatctgctca acgtgctgca gagcctgctg ctcccgttcg ccgtgctgcc catcctcacg ttcaccagca tgcccaccct catgcaggag tttgccaatg gcctgctgaa caaggtcgtc acctcttcca tcatggtgct agtctgcgcc atcaacctct acttcgtggt cagctatctg cccagcctgc cccaccctgc ctacttcggc cttgcagcct tgctggccgc agcctacctg ggcctcagca cctacctggt ctggacctgt tgccttgccc acggagccac ctttctggcc cacagctccc accaccactt cctgtatggg ctccttgaag aggaccagaa aggggagacc Protein function: Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes. [The UniProt Consortium]