SHPRH (Vector pUC, Accession No. BC117686)

Length: 5052 Sequence: ATGAGCAGCC GACGGAAACG TGCTCCTCCA GTGAGGGTAG ATGAGGAAAA GAGGCAGCAG CTTCATTGGA ATATGCATGA GGACAGAAGG AATGAACCTA TCATCATAAG TGATGATGAC GAGCAGCCCT GCCCAGGTTC AGATACCTCT TCTGCTCATT ATATCATTCT AAGTGATAGT CTAAAGGAAG AAGTGGCTCA CAGAGATAAG AAGAGGTGTT CAAAAGTGGT GAGCTTCTCA AAACCAATTG AAAAAGAAGA GACTGTTGGT ATTTTTTCCC CTTTGTCTGT AAAGTTAAAT ATTGTGATTT CTCCCTATCA TTTTGATAAT TCCTGGAAAG CATTTCTAGG AGAATTAACT CTTCAGCTTC TTCCTGCACA GAGTTTAATT GAAAATTTTT CCGAAAGGAG TATTACATTG ATGAGTTCAG AGTCAAGCAA TCAGTTCCTG ATTTATGTTC ATTCAAAAGG TGAAGATGTA GAGAAACAAA AAAAAGAACC GATGAGTATT TGTGACAAGG GTATTCTGGT GGAGTCATCC TTCAGTGGTG AAATGTTAGA AGATTTGGGG TGGCTACAAA AGAAGAGAAG AATAAAACTC TATCAGAAAC CAGAAGGAAA TCACATTATC AAGGTTGGAA TTTATCTTTT GGAAGCTGGC CTAGCAAAAC TAGACTTCTT GAGTGATGCA AATTCAAGAA TGAAAAAGTT CAATCAGCTC ATGAAGAAAG TAATGGAAAA GTTACACAAT TCTATTATTC CAGATGTGTT GGAAGAGGAT GAAGATGATC CGGAGAGTGA GCCAGAGGGA CAAGACATTG ACGAGCTGTA TCACTTTGTG AAACAAACAC ATCAGCAAGA AACGCAGTCC ATCCAAGTGG ATGTCCAGCA TCCTGCATTG ATCCCTGTGT TGAGACCCTA CCAAAGAGAG GCTGTCAATT GGATGCTACA ACAAGAGTGT TTCAGAAGCA GTCCTGCTAC TGAAAGTGCC CTGCACTTCT TATGGCGAGA GATTGTTACA TCTGAGGGTC TGAAACTCTA CTATAATCCA TATACAGGCT GCATCATTCG TGAGTACCCA AATTCTGGGC CGCAGTTGCT TGGTGGAATT TTAGCAGATG AGATGGGTCT TGGAAAGACA GTGGAGGTTT TGGCTCTGAT TCTGACACAT ACTCGACAAG ATGTCAAGCA AGATGCTCTC ACTCTTCCCG AGGGAAAAGT GGTGAATTAT TTTATTCCGT CACATTATTT TGGAGGAAAA CTGAAAAAGA CAGAAATCCA GAATATCGAA TTTGAACCAA AAGAAAAAGT TCAATGCCCT CCTACACGTG TGATGATACT GACAGCTGTG AAAGAAATGA ATGGAAAAAA AGGAGTGTCC ATCCTTTCCA TCTATAAGTA TGTCAGTTCT ATATATAGAT ACGATGTTCA ACGGAACAGG AGTCTTTTGA AACGGATGCT GAAATGTTTA ATTTTTGAAG GTCTCGTGAA ACAGATCAAA GGCCATGGTT TTTCTGGGAC TTTTACATTG GGAAAGAATT ACAAGGAAGA GGATATATGT GATAAAACAA AAAAGCAGGC AGTAGGGAGT CCAAGGAAAA TTCAGAAAGA AACTAGAAAA TCAGGGAACA AGGACACAGA TTCTGAATAC TTGCCATCAG ACACCTCTGA TGATGATGAT GATCCTTACT ATTATTATTA TAAGTCCAGG AGAAATCGCA GTAAATTGAG GAAAAAGCTT GTTCCATCCA CAAAAAAAGG AAAAAGTCAA CCATTTATCA ATCCCGATTC ACAAGGTCAC TGTCCAGCTA CTAGCGACTC TGGAATAACT GATGTTGCTA TGTCTAAAAG TACATGTATC TCTGAATTCA ACCAAGAACA TGAAACAGAG GACTGTGCTG AATCTCTAAA TCATGCTGAT AGTGATGTAC CACCTTCTAA TACCATGAGT CCCTTTAACA CCTCTGATTA CCGCTTTGAG TGTATATGTG GTGAACTTGA TCAGATAGAT CGTAAGCCTC GTGTTCAATG CCTGAAGTGT CACCTGTGGC AACATGCAAA GTGTGTGAAT TATGATGAGA AAAATCTGAA GATCAAGCCT TTTTACTGCC CCCACTGCCT TGTTGCAATG GAACCAGTGT CAACAAGAGC AACTCTGATC ATCTCTCCAA GTTCCATCTG TCACCAGTGG GTGGATGAGA TCAACAGGCA TGTGAGGTCG TCATCTCTTC GAGTCTTGGT ATATCAAGGA GTGAAGAAAG ATGGCTTTTT ACAACCTCAT TTTTTGGCAG AACAGGATAT AGTTATCATT ACCTATGATG TACTGCGTTC AGAATTAAAT TATGTCGATA TCCCACATAG CAATAGTGAG GATGGGCGTC GCCTACGGAA CCAGAAGCGC TATATGGCTA TCCCGAGCCC CCTGGTAGCT GTGGAGTGGT GGAGGATCTG CCTTGATGAA GCTCAGATGG TTGAGTGTCC CACAGTAAAA GCTGCAGAAA TGGCCCAGCG TTTGAGTGGG ATTAATCGAT GGTGTATCAG TGGCACTCCA GTACAGAGAG GATTAGAGGA TCTTTTTGGG TTAGTGGTCT TTCTTGGTAT TGAACCTTAC TGTGTCAAAC ACTGGTGGGT TCGACTTCTC TATCGGCCTT ACTGCAAGAA GAATCCTCAG CATCTCTACA GCTTTATTGC CAAGATACTG TGGAGGTCTG CAAAGAAAGA TGTGATTGAC CAAATCCAAA TACCACCACA AACCGAAGAA ATACACTGGC TCCACTTTTC TCCAGTGGAA AGGCATTTCT ATCACCGTCA GCATGAGGTG TGCTGCCAGG ATGTGGTGGT AAAACTCAGG AAGATTTCTG ACTGGGCTCT GAAGCTCAGC AGCCTAGACA GAAGGACTGT CACCTCTATC CTGTATCCAT TGCTGAGGCT CAGACAGGCC TGCTGTCACC CACAGGCTGT TCGTGGAGAG TTCTTGCCAC TCCAAAAAAG CACCATGACA ATGGAAGAGC TGCTGACATC TTTGCAGAAG AAATGTGGAA CTGAATGTGA AGAAGCACAT CGACAGCTAG TTTGTGCTCT CAATGGCTTA GCAGGCATTC ATATTATTAA AGGTGAGTAT GCCTTGGCAG CAGAATTGTA CAGAGAAGTG TTGCGCTCCT CGGAGGAACA CAAAGGAAAA CTCAAAACTG ATTCACTTCA AAGACTTCAT GCTACCCATA ACTTGATGGA ATTGTTGATA GCCAGGCACC CAGGGATACC ACCTACCTTG CGTGATGGCC GACTTGAGGA AGAGGCCAAA CAGCTGCGAG AGCACTACAT GAGCAAGTGT AATACAGAAG TTGCTGAAGC CCAGCAAGCT TTATATCCTG TGCAGCAGAC CATCCATGAG CTTCAAAGAA AGATTCATTC TAATTCTCCT TGGTGGCTAA ATGTGATCCA CAGAGCAATA GAATTTACTA TTGATGAGGA GCTAGTTCAG CGAGTGCGAA ATGAAATAAC CAGCAACTAC AAGCAACAAA CTGGCAAGCT TTCTATGTCA GAGAAGTTCC GTGATTGCAG AGGTCTTCAG TTCTTACTTA CAACACAAAT GGAAGAGCTA AATAAATGCC AGAAGCTAGT AAGAGAGGCT GTAAAAAACC TGGAGGGACC TCCATCTCGT AATGTTATTG AGTCTGCAAC AGTCTGTCAC CTCCGACCAG CCAGACTTCC TCTCAACTGC TGTGTCTTTT GTAAAGCTGA TGAATTGTTC ACAGAGTATG AATCAAAGCT ATTTTCCAAC ACAGTCAAAG GCCAGACTGC AATATTTGAG GAGATGATAG AAGATGAAGA AGGACTGGTG GATGATCGAG CACCTACCAC CACCCGGGGT CTCTGGGCAA TAAGTGAGAC AGAGCGATCT ATGAAAGCAA TACTATCATT TGCAAAATCA CATAGGTTTG ATGTTGAATT TGTTGATGAA GGAAGCACTT CAATGGATCT CTTTGAAGCA TGGAAGAAGG AATATAAGTT GCTTCATGAA TATTGGATGG CTCTGAGGAA TCGTGTGTCT GCTGTTGATG AACTTGCAAT GGCTACAGAA CGACTAAGAG TGCGTGATCC TAGGGAGCCA AAGCCTAATC CGCCTGTTCT TCATATCATT GAACCACATG AGGTAGAACA AAACCGAATA AAACTACTAA ATGATAAAGC TTTTGCTACA TCACAGCTTC AGAAAAAACT TGGGCAGCTT CTTTACCTAA CTAATTTGGA GAAGTCTCAA GATAAAACAT CGGGAGGTGT TAATCCAGAA CCTTGTCCAA TCTGTGCTCG ACAGCTAGGA AAACAGTGGG CGGTACTGAC CTGTGGTCAC TGTTTCTGTA ATGAATGCAT TTCTATAATT ATTGAACAAT ACAGCGTGGG ATCTCACAGA AGCTCCATTA AGTGTGCAAT CTGCCGCCAG ACCACATCTC ACAAAGAAAT CTCGTATGTC TTTACCTCAG AGAAAGCAAA CCAGGAGGAG GACATCCCTG TGAAGGGCAG CCATTCTACA AAAGTGGAAG CTGTGGTCAG AACTCTGATG AAAATACAGC TTAGAGATCC AGGGGCCAAA GCACTCGTTT TCTCAACGTG GCAAGATGTA TTAGATATTA TTTCAAAAGC TCTTACTGAC AACAACATGG AATTTGCACA AATCAGTCGT GTTAAGACAT TTCAGGAGAA CCTTTCAGCA TTTAAACGTG ATCCCCAAAT CAATATTTTG CTGCTGCCCC TGCACACAGG TTCTAATGGA TTAACTATCA TTGAAGCAAC TCATGTTCTC TTGGTGGAGC CCATATTGAA CCCTGCCCAT GAGCTTCAGG CCATAGGGAG GGTGCACCGA ATTGGACAGA CAAAACCTAC TATTGTACAC AGATTCTTAA TTAAAGCAAC AATAGAAGAA AGAATGCAGG CAATGCTGAA AACTGCTGAG AGAAGTCACA CGAACTCATC AGCAAAGCAT TCAGAGGCCT CTGTCTTGAC TGTGGCTGAC CTGGCAGACC TATTTACCAA AGAAACTGAA GAGCTTGAAT Protein function: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly- ubiquitin chains linked through 'Lys-63'. [The UniProt Consortium]