SH3BP4 (Vector pUC, Accession No. BC057396)

Length: 2892 Sequence: atggcggctc agcggatccg agcggccaac tccaatggcc tccctcgctg caagtcagag gggaccctga ttgacctgag cgaagggttt tcagagacga gctttaatga catcaaagtg ccttctccca gtgccttgct cgtagacaac cccacacctt tcggaaatgc aaaggaagtg attgcgatca aggactattg ccccaccaac ttcaccacac tgaagttctc caagggcgac catctctacg tcttggacac atctggcggt gagtggtggt acgcacacaa caccaccgaa atgggctaca tcccctcctc ctatgtgcag cccttgaact accggaactc aacactgagt gacagcggta tgattgataa tcttccagac agcccagacg aggtagccaa ggagctggag ctgctcgggg gatggacaga tgacaaaaaa gtaccaggca gaatgtacag taataaccct ttctggaatg gggtccagac caatccattt ctgaatggga acgtgcccgt catgcccagc ctggatgagc tgaatcccaa aagtactgtg gatttgctcc tttttgacgc aggtacatcc tccttcaccg aatccagctc agccaccacg aatagcactg gcaacatctt cgatgagctt ccagtcacaa acggactcca cgcagagccg ccggtcaggc gggacaaccc cttcttcaga agcaagcgct cctacagtct ctcggaactc tccgtcctcc aagccaagtc cgatgctccc acatcgtcga gtttcttcac cggcttgaaa tcacctgccc ccgagcaatt tcagagccgg gaggattttc gaactgcctg gctaaaccac aggaagctgg cccggtcttg ccacgacctg gacttgcttg gccaaagccc tggttggggc cagacccaag ccgtggagac aaacatcgtg tgcaagctgg atagctccgg gggtgctgtc cagcttcctg acaccagcat cagcatccac gtgcccgagg gccacgtcgc ccctggggag acccagcaga tctccatgaa agccctgctg gaccccccgc tggagctcaa cagtgacagg tcctgcagca tcagccctgt gctggaggtc aagctgagca acctggaggt gaaaacctct atcatcttgg agatgaaagt gtcagccgag ataaaaaatg acctttttag caaaagcaca gtgggcctcc agtgcctgag gagcgactcg aaggaagggc catatgtctc cgtcccgctc aactgcagct gtggggacac ggtccaggca cagctgcaca acctggagcc ctgtatgtac gtggctgtcg tggcccatgg cccaagcatc ctctaccctt ccaccgtgtg ggacttcatc aataaaaaag tcacagtggg tctctacggc cctaaacaca tccacccatc cttcaagacg gtagtgacca tttttgggca tgactgtgcc ccaaagacgc tcctggtcag cgaggtcaca cgccaggcac ccaaccctgc cccggtggcc ctgcagctgt gggggaagca ccagttcgtt ttgtccaggc cccaggatct caaggtctgt atgttttcca atatgacgaa ttacgaggtc aaagccagcg agcaggccaa agtggtgcga ggattccagc tgaagctggg caaggtgagc cgcctgatct tccccatcac ctcccagaac cccaacgagc tctctgactt cacgctgcgg gttcaggtga aggacgacca ggaggccatc ctcacccagt tttgtgtcca gactcctcag ccacccccta aaagtgccat caagccttcc gggcaaagga ggtttctcaa gaagaacgaa gtcgggaaaa tcatcctgtc cccgtttgcc accactacaa agtacccgac tttccaggac cgcccggtgt ccagcctcaa gtttggtaag ttgctcaaga ctgtggtgcg gcagaacaag aaccactacc tgctggagta caagaagggc gacgggatcg ccctgctcag cgaggagcgg gtcaggctcc ggggccagct gtggaccaag gagtggtaca tcggctacta ccagggcagg gtgggcctcg tgcacaccaa gaacgtgctg gtggtcggca gggcccggcc cagcctgtgc tcgggccccg agctgagcac ctcggtgctg ctggagcaga tcctgcggcc ctgcaaattc ctcacgtaca tctatgcctc cgtgaggacc ctgctcatgg agaacatcag cagctggcgc tccttcgctg acgccctggg ctacgtgaac ctgccgctca cctttttctg ccgggcagag ctggatagtg agcccgagcg ggtggcgtcc gtcctagaaa agctgaagga ggactgtaac aacactgaga acaaagaacg gaagtccttc cagaaggagc ttgtgatggc cctactgaag atggactgcc agggcctggt ggtcagactc atccaggact ttgtgctcct gaccacggct gtagaggtgg cccagcgctg gcgggagctg gctgagaagc tggccaaggt ctccaagcag cagatggacg cctacgagtc tccccaccgg gacaggaacg gggttgtgga cagcgaggcc atgtggaagc ctgcgtatga cttcttactc acctggagcc atcagatcgg ggacagctac cgggatgtca tccaggagct gcacctgggc ctggacaaga tgaaaaaccc catcaccaag cgctggaagc acctcactgg gactctgatc ttggtgaact ccctggacgt tctgagagca gccgccttca gccctgcgga ccaggacgac ttcgtgattt Protein function: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. [The UniProt Consortium]