RBM14 (Vector pUC, Accession No. BC000488)

Length: 2010 Sequence: atgaagatat tcgtgggcaa cgtcgacggg gcggatacga ctccggagga gctggcagcc ctctttgcgc cctacggcac ggtcatgagc tgcgccgtca tgaaacagtt cgccttcgtg cacatgcgcg agaacgcggg cgcgctgcgc gccatcgaag ccctgcacgg ccacgagctg cggccggggc gcgcgctcgt ggtggagatg tcgcgcccaa ggcctcttaa tacttggaag attttcgtgg gcaatgtgtc ggctgcatgc acgagccagg aactgcgcag cctcttcgag cgccgcggac gcgtcatcga gtgtgacgtg gtgaaagact acgcgtttgt tcacatggag aaggaagcag atgccaaagc cgcaatcgcg cagctcaacg gcaaagaagt gaagggcaag cgcatcaacg tggaactctc caccaagggt cagaagaagg ggcctggcct ggctgtccag tctggggaca agaccaagaa accaggggct ggggatacgg ccttccctgg aactggtggc ttctctgcca ccttcgacta ccagcaggct tttggcaaca gcactggtgg ctttgatggg caagcccgtc agcccacacc acccttcttt ggtcgcgacc gcagccctct gcgccgttca cctccccgag cctcttatgt ggctcctctg acggcccagc cagctaccta ccgggcccag ccgtccgtgt cactgggagc tgcctacagg gcccagcctt ctgcctcttt gggtgttggc tatcggactc agcccatgac agcccaggca gcctcttacc gcgctcagcc ctctgtctcc cttggggcac catacagggg ccagctggct agtcctagct cccagtctgc tgcagcttct tcactcggcc catatggtgg agcccagccc tcagcctcgg ccctttcctc ctatgggggt caggcagctg cagcttcttc gctcaactcc tatggggctc agggttcctc ccttgcctcc tatggtaacc agccatcctc ttacggcgcc caggctgcct cttcctatgg ggttcgtgca gctgcttctt cctacaacac ccagggagca gcttcctcct taggctccta cggggctcag gcagcctcct atggggccca gtctgcagcc tcctcactag cttatggagc ccaggcagct tcatataatg cccagccctc ggcctcttac aatgcccagt ctgccccata tgctgcacag caggctgctt cctactcttc ccaacctgct gcctatgtgg cacagccagc cacagctgct gcctatgcca gccagccagc agcctacgcc gcacaagcca ctaccccaat ggctggctcc tatggggccc agccggttgt gcagacccag ctgaatagtt acggggccca agcatcaatg ggcctttcag gctcctatgg ggctcagtcg gctgctgcgg ccactggctc ctatggtgcc gcagcagcct acggggccca accttctgcc accctggcag ctccttaccg cactcagtca tcagcctcat tggctgcttc ctatgctgcc cagcagcatc cccaggctgc tgcctcctac cgcggccagc caggcaatgc ctacgatggg gcaggtcagc cgtctgcagc ctacctgtcc atgtcccagg gggccgttgc caacgccaac agcaccccgc cgccctatga gcgtacccgc ctctccccac cccgggccag ctacgacgat ccctacaaaa aggctgtcgc catgtcgaaa aggtatggtt ccgaccggcg tttagccgag ctctctgatt accgccgttt atcagagtcg cagctttcgt tccgccgctc gccgacaaag tcctcgctgg attaccgtcg cctgcccgat gcccattccg attacgcacg ctattcgggc tcctataatg attacctgcg ggcggctcag atgcactctg gctaccagcg Protein function: Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). [The UniProt Consortium]