PSME4 (Vector pUC, Accession No. BC112169)

Length: 5190 Sequence: atgatgcagg gatttgcccg ccttttgatc aacttgttaa agaaaaagga acttctttca agagctgatt tggagttacc ctggagacca ctttatgaca tggtagaaag aatattatat tccaagacag agcacctagg attaaattgg tttcctaatt ctgtagaaaa tattctcaaa acactcgtga aaagctgccg accatatttt ccagcagatg ccaccgctga gatgctagaa gaatggcgac ctttaatgtg cccttttgat gtaaccatgc aaaaggccat cacttatttt gaaatatttc ttcctacctc ccttcctcca gaacttcatc ataaaggttt taaactttgg tttgatgaat taattggcct ttgggtttca gtgcaaaatc tcccacaatg ggaggggcaa ctagtaaatc tctttgctcg attggctaca gataatatag ggtacataga ttgggatcca tatgtaccaa agatatttac aagaattctg agaagcttga acctcccagt gggaagcagt caagtgttag tcccaagatt tttaacaaat gcttatgata taggacatgc tgtaatatgg atcaccgcca tgatgggtgg accaagtaag ctagtgcaaa aacacttagc tggtttgttt aacagcatca catcttttta ccatccttca aataatgggc gctggctgaa caagttaatg aaactacttc agcggttgcc aaacagtgtt gttagaagat tgcatcgtga aagatacaag aagccctctt ggttaactcc tgtgcctgat agccacaagc ttactgatca agatgttaca gactttgtac aatgcattat tcagcctgtc ctcttggcta tgtttagcaa aaccggtagt ctagaagcag cccaggcttt gcagaatctt gcactcatga gacctgaatt ggtaataccc cctgtacttg aaagaacata tcctgcatta gagacattaa cagaacctca ccagctcaca gctactttaa gttgtgtaat tggagtagcc cgcagtttgg tatcaggagg cagatggttt cctgaaggtc ctacacatat gctacctctg ttgatgagag cattgcctgg ggtggatcca aatgacttta gtaaatgcat gatcacattc cagttcatag caacattttc tactctggtg cctttagtag attgttcatc tgtactacaa gaaagaaatg acctcacaga agtggaacga gaactttgtt cagccacagc tgaatttgag gatttcgtct tacagtttat ggacagatgt tttggactta tagaaagtag cacattggag caaacaagag aagagacaga aactgagaaa atgacacact tggagagttt ggtcgaatta ggtctgtctt ctacgtttag tacaatcctc acccaatgtt ccaaagaaat atttatggtg gcccttcaga aggtttttaa tttttctact tcacatatat ttgaaacaag agtagcaggt cgcatggtgg cagacatgtg ccgcgctgct gtaaagtgct gcccagaaga atctttgaag ctctttgttc cccactgctg cagtgttata actcagctta caatgaatga tgatgtatta aatgatgaag agctagacaa ggaattacta tggaatcttc aacttttgtc tgagattact cgagtggatg gaaggaagtt gcttctttat agggagcagc ttgtaaagat tctccaaaga accctacatt taacctgtaa gcagggttac actctgtctt gtaacctttt gcatcatctt ctccgttcta ccacacttat ctaccctaca gaatactgca gtgtgccagg tggctttgac aagcctcctt ctgaatactt tcctatcaag gactggggca aacccgggga cttgtggaat ctgggaatcc agtggcatgt tccttcttca gaagaagtgt cttttgcctt ttatcttttg gactcctttc ttcagcctga gctcgtcaaa ctccagcatt gtggggatgg aaaacttgaa atgtctagag atgatattct acagagtctg actatagtgc acaactgttt aattggctct ggaaacctcc tacctccgtt gaaaggagag ccagttacta acttagtacc aagtatggtg tccttggaag agacaaagtt gtatactgga cttgaatatg atctgtctcg agagaaccac cgagaagtaa ttgctacagt tataaggaaa cttcttaacc acatacttga taattcagaa gatgatacta agtcattgtt tcttattata aagattattg gagacctttt acaattccaa ggatctcaca agcatgaatt tgactcccga tggaaaagct tcaacttagt aaagaaatca atggaaaatc ggctccatgg gaaaaaacaa catatcagag cactgttgat tgatagagta atgttacagc atgagctacg gacactaact gttgagggtt gtgaatacaa aaagatacat caagatatga tcagagatct tcttcgttta tctacaagtt catacagtca ggtgagaaat aaggctcagc aaacattttt tgctgccttg ggagcatata acttctgttg cagagatatc attcccttgg ttttggagtt cttaaggcct gatagacaag gtgttacaca gcaacaattc aagggtgcct tgtactgtct ccttggaaat cacagtggtg tgtgcttggc aaaccttcat gattgggact gtattgtaca gacgtggcca gcgattgttt cttcagggct tagccaagca atgtccctgg aaaagccatc aatagtgaga ttgtttgatg atcttgcaga aaagattcat aggcagtatg aaacaattgg cttggacttc acaattccaa agtcatgtgt tgaaatagcg gaattacttc aacagtcaaa aaacccctct atcaaccaga tattgcttag cccagaaaaa attaaggaag gaattaaacg ccaacaggaa aagaatgccg atgccctaag gaactatgaa aatttggtag acaccttgct agatggtgtg gagcaaagaa acctgccctg gaaatttgaa catataggca ttgggcttct gtctctactg ctgagagatg accgagtgtt gcctcttcgt gccatacggt tttttgttga gaatctcaac catgatgcaa ttgtagttcg aaagatggct atctcagctg ttgctggtat ccttaaacag ctaaaaagaa cccacaaaaa gctgaccatt aacccctgtg aaatcagtgg atgccctaaa cccacccaaa ttattgctgg tgataggcct gataatcatt ggttgcatta tgacagcaaa actataccaa gaactaaaaa agaatgggag tcaagttgct ttgtggaaaa aactcactgg ggatactaca cctggccaaa gaatatggtt gtttatgctg gtgtggaaga gcagcctaag cttggcagaa gcagggagga tatgacagag gcagaacaga ttatatttga tcatttttct gatcctaaat ttgttgagca gttaattact tttctatcat tagaagacag aaaaggaaaa gataagttta atccacgacg tttttgcctc tttaagggta tattcaggaa ttttgatgat gccttcctgc cagttctgaa gccccattta gaacatttgg ttgcagattc acatgaaagc acccagcgat gtgttgcaga aattatagct ggtttaatca gaggttctaa gcactggaca tttgaaaagg tggagaagct ttgggagctt ctgtgccctc tgcttagaac agcactgtcc aatattaccg tagaaactta taatgactgg ggagcttgta tagcaacatc ctgtgaaagc agagatcccc ggaaacttca ctggcttttt gaactgctgt tggaatcacc attgagtggt gaaggaggat cctttgtaga tgcatgtcga ctttatgtac tacaaggtgg ccttgcccag caagaatgga gagtgcctga actattgcac agactactga agtacttgga acccaaactc acccaggttt acaaaaatgt cagagaaaga ataggaagtg tgctgaccta catattcatg atagatgtat ctttgccaaa taccacacca accatatcgc ctcatgtccc tgagtttact gctcgaattc tggagaaatt gaaacctctc atggatgtgg atgaagaaat tcagaaccat gttatggaag aaaatggaat tggtgaagaa gatgagcgaa ctcagggcat taaactcttg aaaaccatat tgaaatggct gatggcaagt gcaggaagat ccttttctac agcagttaca gaacaacttc agcttctacc tttgtttttc aagattgccc cagtggaaaa tgacaatagc tacgatgaac tgaaaagaga tgcaaagtta tgtttatcat taatgtctca ggggttgctt taccctcatc aagtgccttt ggtacttcag gtgctaaaac aaacagcaag aagcagttct tggcatgcac gatacacagt actgacctac ctccagacca tggtatttta taacctcttt attttcctaa acaatgaaga tgcagttaaa gatatcaggt ggctggttat aagtcttttg gaggacgaac aactggaggt tcgagaaatg gctgctacta ccttaagcgg tctgctacag tgtaactttc ttaccatgga cagtcctatg cagattcatt ttgagcaact ttgcaaaaca aaactaccta agaaaagaaa gcgagaccct ggttctgtag gagataccat tccttctgca gagttggtca aacgccatgc tggggtgcta ggacttggtg catgtgttct ttctagtcct tacgatgttc ccacctggat gccccagctc ctcatgaatc tcagtgcaca tctaaatgat cctcagccta ttgagatgac tgtaaaaaaa accttatcca atttccgaag gactcaccat gacaactggc aggaacataa acagcaattc actgatgacc aactgcttgt tctcaccgat cttcttgtgt caccatgcta Protein function: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. [The UniProt Consortium]