PRELID1 (Vector pUC, Accession No. BC000007)

Length: 660 Sequence: atggtgaagt atttcctggg ccagagcgtg ctccggagtt cctgggacca agtgttcgcc gccttctggc agcggtaccc gaatccctat agcaaacatg tcttgacgga agacatagta caccgggagg tgacccctga ccagaaactg ctgtcccggc gactcctgac caagaccaac aggatgccac gctgggccga gcgactattt cctgccaatg ttgctcactc ggtgtacgtc ctggaggact ctattgtgga cccacagaat cagaccatga ctaccttcac ctggaacatc aaccacgccc ggctgatggt ggtggaggaa cgatgtgttt actgtgtgaa ctctgacaac agtggctgga ctgaaatccg ccgggaagcc tgggtctcct ctagcttatt tggtgtctcc agagctgtcc aggaatttgg tcttgcccgg ttcaaaagca acgtgaccaa gactatgaag ggttttgaat atatcttggc taagctgcaa ggcgaggccc cttccaaaac acttgttgag acagccaagg aagccaagga gaaggcaaag gagacggcac tggcagctac agagaaggcc aaggacctcg ccagcaaggc ggccaccaag aagcagcagc agcagcaaca Protein function: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4- induced Th2 cell number. May be important for the development of vital and immunocompetent organs. [The UniProt Consortium]