PDZD8 (Vector pUC, Accession No. BC028375)

Length: 3465 Sequence: atggggctgc tgctcatgat cctggcgtcg gccgtgctgg gttccttcct cacgctcctc gcccagttct tcctgctgta ccgcagacag cccgagccgc cggcggacga ggccgcccgc gcgggcgagg gcttccgcta catcaagcca gtgccgggcc tgctcctaag ggagtacctt tatggcggcg gccgggatga ggagccctcc ggagcggccc ctgagggcgg cgcgaccccc accgcggccc ccgagacccc cgccccgccg acgcgggaga cttgctactt cctcaacgcc accatcctat tcctgttccg ggagttgcgg gacaccgcgc tgacccgccg ctgggtcacc aagaagatca aggtggagtt cgaggagctg ctgcagacca agacggccgg gcgcctgctg gaggggctga gcctgcggga cgtgttcctg ggcgagacgg tgcccttcat caagaccatc cggctcgtgc ggccagtcgt gccctcggcc accggggagc ccgatggccc tgaaggggag gcgctgcccg ccgcctgccc cgaggagctg gccttcgagg cggaggtgga gtacaacggg ggcttccacc tggccatcga cgtggacctg gtcttcggca agtccgccta cttgtttgtc aagctgtccc gcgtggtggg aaggctgcgc ttggtcttta cgcgcgtgcc cttcacccac tggttcttct ccttcgtgga agacccgctg atcgacttcg aggtgcgctc ccagtttgaa gggcggccca tgccccagct cacctccatc atcgtcaacc agctcaagaa gatcatcaag cgcaagcaca ccctaccgaa ttacaagatc aggtttaagc cgttttttcc ataccagacc ttgcaaggat ttgaagaaga tgaagagcat atccatatac aacaatgggc acttactgaa ggccgtctta aagttacgtt gttagaatgt agcaggttac tcatttttgg atcctatgac agagaggcaa atgttcattg tacacttgag ttaagcagta gtgtttggga agaaaaacag aggagttcta ttaagacggt tgaattaata aaaggaaatt tacaaagtgt tggacttaca cttcgtcttg tccagtcaac tgatgggtat gctgggcacg tcatcattga aactgtggct ccaaactcgc ctgctgcaat tgcagatctt cagcggggag atcgacttat cgccattgga ggtgtgaaaa tcacatcaac actgcaagtg ttgaagctta tcaagcaggc tggtgaccga gtcctggtgt actatgaaag gcctgttggc cagagtaatc aaggtgcagt gctgcaagat aactttggcc agttggaaga aaactttttg tcaagctcat gccaatcggg ttatgaagag gaagctgccg ggttgacagt agatactgaa agtagagagc tggattctga atttgaagac ttggcaagtg atgtcagagc acaaaatgag ttcaaagatg aggcacaatc attaagtcat agtcccaaac gtgttccaac aacactttct attaaacccc ttggagctat atcaccagtt ttaaaccgta aattagctgt aggaagtcac ccactaccac cgaaaattca gtccaaagat ggaaataaac ctccacccct aaaaacttct gagataacag acccagcaca agtgtcaaaa ccaacccaag gatctgcttt caaaccacct gtgccaccac gaccacaagc gaaagttcct ttgccttccg ccgatgctcc aaatcaggca gaaccagatg ttctcgttga aaagccagag aaggtggtgc cacctcctct tgtagataaa tctgctgaaa agcaagcaaa aaatgtggat gccatagacg atgcagctgc acctaagcaa tttttagcaa agcaagaagt ggccaaagat gtcacttcag aaacttcctg ccctactaag gacagttcgg acgaccgtca aacatgggaa tcatcagaaa ttctttatcg taataagcta ggaaaatgga caagaaccag agcatcctgt ttgtttgaca tagaagcctg tcacaggtac ttaaacattg cattgtggtg cagggatcct ttcaagttgg gaggtctcat ctgtttgggg catgttagtt taaaacttga agatgtggct ttaggatgcc tagctacatc aaacacggaa tacctttcca aattgagact ggaagccccc tcacctaagg ctatagtcac tagaaccgca ctacgcaatc tgagtatgca aaagggattc aatgacaaat tttgctatgg tgacattact attcacttca aatatttgaa agaaggagaa tcagaccacc atgtagttac taacgtagaa aaagaaaaag aaccccattt ggttgaagaa gtttctgttc tccctaaaga ggagcaattt gttggacaga tgggtttaac agaaaacaaa cacagttttc aggatactca gttccagaac ccaacatggt gtgactactg taagaaaaaa gtttggacta aagcagcttc ccagtgtatg ttttgtgctt atgtttgcca taaaaaatgt caagaaaagt gtctagctga gacttctgtt tgtggagcaa ctgataggcg aatagacagg acactgaaaa accttaggct ggaaggacag gaaaccctct taggcctgcc tcctcgtgtt gatgctgaag ctagcaagtc agtcaataaa acaacaggtt tgacaaggca tattatcaat actagttctc gtttattaaa tttgcgtcaa gtctctaaaa ctcgcctttc tgaaccagga accgatctcg tagaaccttc accaaaacac acacccaaca cgtcagacaa cgaaggcagt gacacggagg tctgtggtcc aaacagtcct tctaaacggg gaaacagcac aggaataaag ttagtgagaa aagagggtgg tctggatgac agtgttttca ttgcagttaa agaaattggt cgtgatctgt acaggggctt gcctacagag gaaaggatcc agaaactaga gttcatgttg gataagctac agaatgaaat tgatcaggag ttggaacaca ataattccct tgttagagaa gaaaaagaga caactgatac aaggaaaaaa tcacttcttt ctgctgcctt agctaaatca ggtgaaaggc tacaagctct aacacttctt atgattcact acagagcagg cattgaagat atagaaactt tagaaagtct gtctttagac cagcactcca aaaaaataag caagtacaca gatgatacag aagaagacct tgataatgaa ataagccaac taatagactc tcagccattc agcagcatat cagatgactt atttggccca tccgagtctg Protein function: Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes (PubMed:29097544). PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer (PubMed:29097544). In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons (PubMed:29097544). Plays an indirect role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). May inhibit herpes simplex virus 1 infection at an early stage (PubMed:21549406). [The UniProt Consortium]