PARP16 (Vector pUC, Accession No. BC031074)

Length: 969 Sequence: atgcagccct caggctgggc ggccgccagg gaggcggcgg gccgcgacat gctggccgcc gacctccggt gcagcctctt cgcctcggcc ctgcagagct acaagcgcga ctcggtgctg cggcccttcc ccgcgtccta cgcccgcggc gactgtaagg actttgaagc cctgcttgca gatgccagca agttacctaa cctgaaagaa cttctccagt cctccggaga caaccacaaa cgggcctggg acctggtgag ctggatttta tcctcaaagg tcctgacaat ccacagtgca gggaaggcag agtttgaaaa gatccaaaag ctgactgggg ctcctcacac gcctgttcct gcaccggact tcctgtttga aattgagtac tttgacccag ccaacgccaa attttatgag accaaaggag aacgagacct aatctatgca tttcatggta gccgcctaga aaacttccat tccattatcc acaatggcct gcactgccat ctgaacaaga catccttgtt cggagagggg acctacctca ccagtgactt aagcctggcc ctcatataca gcccccatgg ccatgggtgg cagcacagcc tcctcggccc catccttagc tgtgtggccg tgtgtgaggt cattgaccat ccggacgtca agtgccaaac caagaagaag gattccaagg agatagatcg cagacgagcg agaatcaaac atagtgaagg gggagacatc cctcccaagt acttcgtggt caccaataac cagctgctgc gagtgaagta cctcctggtg tattcacaga agccacccaa gagggctccg agccagctct cctggttttc cagccattgg tttaccgtca tgatatccct gtatctgctg ctgctgctca tagtgagtgt catcaactcc tctgctttcc aacacttttg gaatcgtgcg Protein function: Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP- ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565). [The UniProt Consortium]