MXRA8 (Vector pUC, Accession No. BC006213)

Length: 1329 Sequence: atggcgctgc catcccgaat cctgctttgg aaacttgtgc ttctgcagag ctctgctgtt ctcctgcact cagggtcctc ggtacccgcc gctgctggca gctccgtggt gtccgagtcc gcggtgagct gggaggcggg cgcccgggcg gtgctgcgct gccagagccc gcgcatggtg tggacccagg accggctgca cgaccgccag cgcgtgctcc actgggacct gcgcggcccc gggggtggcc ccgcgcggcg cctgctggac ttgtactcgg cgggcgagca gcgcgtgtac gaggcgcggg accgcggccg cctggagctc tcggcctcgg ccttcgacga cggcaacttc tcgctgctca tccgcgcggt ggaggagacg gacgcggggc tgtacacctg caacctgcac catcactact gccacctcta cgagagcctg gccgtccgcc tggaggtcac cgacggcccc ccggccaccc ccgcctactg ggacggcgag aaggaggtgc tggcggtggc gcgcggcgca cccgcgcttc tgacctgcgt gaaccgcggg cacgtgtgga ccgaccggca cgtggaggag gctcaacagg tggtgcactg ggaccggcag ccgcccgggg tcccgcacga ccgcgcggac cgcctgctgg acctctacgc gtcgggcgag cgccgcgcct acgggcccct ttttctgcgc gaccgcgtgg ctgtgggcgc ggatgccttt gagcgcggtg acttctcact gcgtatcgag ccgctggagg tcgccgacga gggcacctac tcctgccacc tgcaccacca ttactgtggc ctgcacgaac gccgcgtctt ccacctgacg gtcgccgaac cccacgcgga gccgcccccc cggggctctc cgggcaacgg ctccagccac agcggcgccc caggcccaga ccccacactg gcgcgcggcc acaacgtcat caatgtcatc gtccccgaga gccgagccca cttcttccag cagctgggct acgtgctggc cacgctgctg ctcttcatcc tgctactggt cactgtcctc ctggccgccc gcaggcgccg cggaggctac gaatactcgg accagaagtc gggaaagtca aaggggaagg atgttaactt ggcggagttc gctgtggctg caggggacca gatgctttac aggagtgagg acatccagct agattacaaa aacaacatcc tgaaggagag ggcggagctg gcccacagcc ccctgcctgc caagtacatc gacctagaca aagggttccg gaaggagaac Protein function: Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:22492581, PubMed:23386276). Mediates heterophilic cell-cell interactions in vitro. Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38. Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes. Stimulates formation of primary cilia in chondrocytes. Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH, may also promote signaling via the PTHLH/PTHrP pathway. Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed:23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed:23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed:23386276). May play a role in the maturation and maintenance of the blood-brain barrier. [The UniProt Consortium]